mPEG-SH is linear monofunctional PEG with a reactive free thiol, SH, cysteine, sulfhydryl, or mercapto group that selectively reacts with maleimide and transition metal surface including gold, silver, etc. mPEG-SH can be easily air oxidized to form a dimer via a S-S disulfide bond, which can be reversed with reducing agents. It is a useful reagent for reversible PEGylation.

References: 1. PEGylation of Nanorods – Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors, Nuclear Medicine and Biology 41 (2014) 282–289,Text.

2. PEGylation of Nanoparticles – Detecting protein adsorption and binding using magnetic nanoparticle probes, Sensors and Actuators B 160 (2011) 650– 655, Text.

3. Surface PEGylation of Gold Nanorods – Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood , J. Biomed. Opt. 17(10), 106016 (Oct 17, 2012), Text.

4. Surface PEGylation of Gold Nanorods – Conjugation of antibodies to gold nanorods through Fc portion: synthesis and molecular specific imaging, Bioconjug Chem. 2013 June 19; 24(6): 878–888, Text.

5. PEGylation of Metallic Nanoparticles – Plasmon-Resonant Gold Nanoparticles with Variable Morphology as Optical Labels and Drug Carriers for Cytological Research, Proc. of SPIE-OSA/ Vol. 8801 880102-2,Text.

6. Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer, Nano Lett. 2009 Aug; 9(8): 2825–2831, Text

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