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英文版：Snake Venom Proteins
|
Activator |
Source |
Application |
Remarks |
|
|
|
||
|
113-01 / 113-04 |
Protac® |
• Determination of protein C and protein S |
Serine protease Agkistrodon contortrix |
|
116-01 |
Ecarin |
• Prothrombin assay |
Metalloprotease, activates specifically prothrombin via meizothrombin, does not need PL and Ca2+ Echis carinatus |
|
119-02 |
Convulxin |
Activation of human plaets via binding and clustering of GPVI-receptors under physiological conditions |
Crotalus durissus |
|
121-03 |
RVV Factor V-Activator |
Activation of FV in APC-R assay |
Serine protease, not inhibited by AT |
|
121-06 |
RVV-X |
• Determination of FX |
Metalloprotease, does also (weakly) activate protein C and factor IX Daboia (Vipera) russelli |
|
800191 |
Pefakit® Reptilase® Time |
Ready-to-use diagnostic reagent for measurement of |
CE-marked IVD Bothrops atrox |
中文版：
蛇毒蛋白质
|
活化剂 |
资源 |
应用 |
备注 |
|
113-01 / 113-04 |
Protac® |
•蛋白C和蛋白S的 |
丝氨酸蛋白酶Agkistrodon contortrix |
|
116-01 |
蝰蛇毒 |
•凝血酶原测定 |
金属蛋白酶，通过凝血酶原特异性激活凝血酶原，不需要PL和Ca2 + Echis carinatus |
|
119-02 |
惊厥 |
在生理条件下通过结合和聚集GPVI-受体激活人血小板 |
响尾蛇durissus |
|
121-03 |
RVV因子V激动剂 |
在APC-R测定中激活FV |
丝氨酸蛋白酶，不受AT抑制 |
|
121-06 |
RVV-X |
•FX的测定 |
金属蛋白酶，也（弱）激活蛋白C和因子IX Daboia（Vipera）russelli |
|
800191 |
Pefakit®Reptilase®时间 |
即用型诊断试剂，用于测量 |
CE标记的IVD Bothrops atrox |
附件为113-01说明书。
Description: Protac, a single chain glycoprotein, is a fast-acting protein C activator isolated from the venom of the copperhead snake Agkistrodon contortrix and closely related snake species. This serine proteinase rapidly converts protein C of man and other vertebrates into activated protein C which may be determined either by measuring its prolonging effect on the activated partial thromboplastin time (APTT) or by measuring its enzyme activity by means of a specific
|
|
chromogenic substrate. |
|
|
Application: |
Determination of protein C and protein S levels. |
|
|
Origin: |
Agkistrodon contortrix snake venom |
MW: 36’000 to 42’000 |
|
Assay: |
Chromogenic method |
Clotting method |
|
|
0.050 ml human citrated plasma |
0.025 ml human citrated plasma |
|
|
0.050 ml Protac (0.5 unit/ml) |
0.025 ml Protac (0.1 unit/ml) |
|
|
=> incubate for 5 min at 37°C |
0.025 ml Actin |
|
|
0.800 ml 50 mM Tris-HCl buffer, pH 8.4 |
=> incubate for 4 min at 37°C |
|
|
0.100 ml PefachromePCa (4 mM) => Determination of DOD/min at 405 nm |
0.025 ml 25 mM CaCl2 => Determination of clotting time |
Unit definition: 1 Unit is the amount of Protac which activates the amount of protein C contained in 1 ml of normal citrated human plasma within 5 min at 37°C.
|
Stability: |
Lyophilised vials: Reconstituted vials: |
5 years 30 days at 2 – 8°C, approx. 7 days at 37°C |
|
|
|
1 year at -20°C, 1 month at 20°C. |
Storage: May be used by the expiry date given on the label when stored unopened, protected from moisture, in the dark, 2 – 8°C. Avoid contamination of the reagents by micro-organisms. Shipment of product does not require cooling during the time of transportation.
References: Bastian S. Protein C-Diagnostik – Methoden, Interpretation und Limitationen. ellipse 2002; 18 (1): 11-16
Gempeler-Messina PM, Volz K, Bühler B, Müller C. Protein C Activators from Snake Venoms and Their Diagnostic Use. Haemostasis 2001; 31:266-72.
Robert A, Eschwege V, Hameg H, Drouet L, Aillaud MF. Anticoagulant response to Agkistrodon contortrix venom (ACV test): a new global test to screen for defects in the anticoagulant protein C pathway. Thromb Haemost 1996; 75: 562-66.
Kraus M, Noah M, Fickenscher K. The PCAT – a simple screening assay for assessing the functionality of the protein C anticoagulant pathway. Thromb Res 1995; 79: 217-22.
Meier J, Stocker K. Snake venom protein C activators. In: Handbook of Natural Toxins, Reptile Venoms and Toxins. Tu AT, ed. New York: Marcel Dekker 1990; 265-79.
Stocker K, Fischer H, Meier J, Brogli M, Svendsen L. Characterization of the protein C activator Protac from the venom of the southern copperhead (Agkistrodon contortrix) snake. Toxicon 1987; 25: 239-52.
|
Package size: |
Vial containing 3 unit/vial Code: |
113-01 |
|
|
Bulk [unit] |
113-04 |
|
|
FOR RESEARCH USE ONLY. NOT FOR HUMAN USE OR DRUG USE. |
|
Pentapharm 2018年产品列表
|
货号 |
品名 |
规格 |
目录价 |
品牌 |
|
081-01 |
Pefachrome® TH 5244 |
25 mg |
3000.00 |
Pentapharm |
|
081-05 |
Pefachrome® TH 5247 |
25 mg |
3000.00 |
Pentapharm |
|
081-09 |
Pefachrome® TH 5251 |
25 mg |
3000.00 |
Pentapharm |
|
081-11 |
Pefachrome® FXIIa/TH 5253 |
25 mg |
3000.00 |
Pentapharm |
|
081-45 |
Pefachrome® 6017 |
10 µmol |
3000.00 |
Pentapharm |
|
081-15 |
Pefachrome® TH 5256 |
25 mg |
3000.00 |
Pentapharm |
|
081-17 |
Pefachrome® TG |
25 mg |
3000.00 |
Pentapharm |
|
081-66 |
Pefachrome® TH 8198 |
25 mg |
3000.00 |
Pentapharm |
|
082-33 |
Pefachrome® uPA 8294 |
25 mg |
3000.00 |
Pentapharm |
|
083-01 |
Pefachrome® PL/Tryp 5261 |
25 mg |
3000.00 |
Pentapharm |
|
083-02 |
Pefachrome® PL 5262 |
25 mg |
3000.00 |
Pentapharm |
|
083-03 |
Pefachrome® PL 5263 |
25 mg |
3000.00 |
Pentapharm |
|
083-04 |
Pefachrome® PL 5264 |
25 mg |
3000.00 |
Pentapharm |
|
084-01 |
Pefachrome® TRY 5274 |
25 mg |
3000.00 |
Pentapharm |
|
085-01 |
Pefachrome® FXa 5277 |
25 mg |
3000.00 |
Pentapharm |
|
085-03 |
Pefachrome® FXa 5279 |
25 mg |
3000.00 |
Pentapharm |
|
085-06 |
Pefachrome® FXa/LAL 5288 |
25 mg |
3000.00 |
Pentapharm |
|
086-11 |
Pefachrome® LAL 5288 |
100 μmol |
6000.00 |
Pentapharm |
|
085-27 |
Pefachrome® FXa 8595 |
25 mg |
3000.00 |
Pentapharm |
|
802050 |
Pefachrome® FXa 2732 |
25 mg |
3000.00 |
Pentapharm |
|
087-03 |
Pefachrome® C1E |
25 mg |
3000.00 |
Pentapharm |
|
089-02 |
Pefachrome® PCa |
25 mg |
3000.00 |
Pentapharm |
|
091-01 |
Pefachrome® tPA |
25 mg |
3000.00 |
Pentapharm |
|
091-03 |
Pefachrome® tPA5312 |
25 mg |
3000.00 |
Pentapharm |
|
093-01 |
Pefachrome® FVIIa |
25 mg |
3000.00 |
Pentapharm |
|
095-20 |
Pefachrome® FIXa |
10 μmol |
1500.00 |
Pentapharm |
|
801058 |
Pefafluor® TH |
25 mg |
3600.00 |
Pentapharm |
|
073-70 |
Aprotinin Conc. Solution (vial 50 ml) |
Mio KIU |
1500.00 |
Pentapharm |
|
800277 |
Aprotinin Powder, lyoph. (vial 1 g) |
Mio KIU |
1200.00 |
Pentapharm |
|
126-10 |
r-Hirudin EC |
2000 ATU |
3200.00 |
Pentapharm |
|
381-01 |
Pefabloc® TH (α-NAPAP) |
5 mg |
1800.00 |
Pentapharm |
|
399-01 |
Pefabloc® SC |
1 g |
2200.00 |
Pentapharm |
|
399-01 |
Pefabloc® SC |
10 g |
20000.00 |
Pentapharm |
|
099-01 |
Pefabloc® FG |
1 g |
11600.00 |
Pentapharm |
|
099-11 |
Pefabloc® FG |
50 mg |
1200.00 |
Pentapharm |
|
101-04 |
Batroxobin maranhao |
100 BU |
2500.00 |
Pentapharm |
|
101-06 |
Batroxobin maranhao |
1000 BU |
22500.00 |
Pentapharm |
|
113-01 |
Protac® |
3 U |
780.00 |
Pentapharm |
|
113-05 |
Protac® solution 10 U/ml |
1 ml |
2400.00 |
Pentapharm |
|
116-01 |
Ecarin |
50 EU |
1980.00 |
Pentapharm |
|
119-02 |
Convulxin |
50 µg |
8600.00 |
Pentapharm |
|
121-03 |
RVV-Factor V Activator |
1000 U |
6000.00 |
Pentapharm |
|
121-06 |
RVV Factor X Activator |
5 U |
1000.00 |
Pentapharm |
|
121-07 |
RVV-Factor X-Activator |
50 U |
6000.00 |
Pentapharm |
|
502-01 |
Pefakit® APC-R Factor V Leiden 3 x 40 tests |
Kit |
3600.00 |
Pentapharm |
|
502-21 |
Pefakit® APC-R Factor V Leiden Controls |
Kit |
1100.00 |
Pentapharm |
|
505-01 |
Pefakit® PiCT® |
Kit |
4000.00 |
Pentapharm |
|
505-22 |
Pefakit® PiCT® Controls UFH |
Kit |
3900.00 |
Pentapharm |
|
800186 |
Pefakit® TAFI |
Kit |
10000.00 |
Pentapharm |
|
800187 |
Pefakit® TAFI Controls and Calibration |
Kit |
6000.00 |
Pentapharm |
|
800191 |
Pefakit® Reptilase® Time |
Kit |
2800.00 |
Pentapharm |
|
069-03 |
Prionex® 10% |
100 ml |
2000.00 |
Pentapharm |
|
069-03 |
Prionex® 10% |
500 ml |
9000.00 |
Pentapharm |
|
069-03 |
Prionex® 10% |
1000 ml |
12000.00 |
Pentapharm |
|
801682 |
Rabbit brain cephalin |
100mg |
12000.00 |
Pentapharm |
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