多肽定制Mca-Amyloid b/A4 Protein Precursor770 (667-676)-Lys(DNP)-Arg-Arg amide 编码

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名称 Mca-Amyloid b/A4 Protein Precursor770 (667-676)-Lys(DNP)-Arg-Arg amide
编码
别名 Mca-Amyloid b/A4 Protein Precursor770 (667-676)-Lys(DNP)-Arg-Arg amide
纯度 80%,90%,95%,98%,99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列(单字母缩写) Mca-SEVKMDAEFR-K(DNP)-RR-NH2
序列(三字母缩写) Mca-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-Lys(DNP)-Arg-Arg-NH2?(trifluoroacetate salt)
基本描述 Very sensitive and internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1), a membrane-bound zinc metallopeptidase that is related to neprilysin in amino acid sequence. The kcat/Km value for the hydrolysis by ECE-1 was 1.9 x 10^7 M-1s-1and 1.7 x 10^6 M-1s-1聽for the hydrolysis by neprilysin. For MMP-2, MMP-9 the kcat/Km values are in the range of 10^4 M-1s-1聽whereas for MMP-1 there was no hydrolysis observed. This peptide was hydrolyzed rapidly by stromelysin 1 (MMP-3) with kcat/Km = 218000 M-1s-1and very slowly by gelatinase B (MMP-9) (kcat/Km=10100 M-1s-1). There was no hydrolysis by MMP-1 and MMP-2 observed.
溶解度
分子量 2033.2
化学式 C87H129N27O28S1
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Mca-Amyloid b/A4 Protein Precursor770 (667-676)-Lys(DNP)-Arg-Arg amide          编码
Figures Mca-Amyloid b/A4 Protein Precursor770 (667-676)-Lys(DNP)-Arg-Arg amide          编码
Reference H. Koike et al., J. Biochem., 126, 235 (1999)
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