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名称 | Mca-Amyloid b/A4 Protein Precursor770 (667-676)-Lys(DNP)-Arg-Arg amide |
编码 | |
别名 | Mca-Amyloid b/A4 Protein Precursor770 (667-676)-Lys(DNP)-Arg-Arg amide |
纯度 | 80%,90%,95%,98%,99% |
重量 | 1mg,5mg,10mg,50mg,100mg,1g |
序列(单字母缩写) | Mca-SEVKMDAEFR-K(DNP)-RR-NH2 |
序列(三字母缩写) | Mca-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-Lys(DNP)-Arg-Arg-NH2?(trifluoroacetate salt) |
基本描述 | Very sensitive and internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1), a membrane-bound zinc metallopeptidase that is related to neprilysin in amino acid sequence. The kcat/Km value for the hydrolysis by ECE-1 was 1.9 x 10^7 M-1s-1and 1.7 x 10^6 M-1s-1聽for the hydrolysis by neprilysin. For MMP-2, MMP-9 the kcat/Km values are in the range of 10^4 M-1s-1聽whereas for MMP-1 there was no hydrolysis observed. This peptide was hydrolyzed rapidly by stromelysin 1 (MMP-3) with kcat/Km = 218000 M-1s-1and very slowly by gelatinase B (MMP-9) (kcat/Km=10100 M-1s-1). There was no hydrolysis by MMP-1 and MMP-2 observed. |
溶解度 | |
分子量 | 2033.2 |
化学式 | C87H129N27O28S1 |
存储条件 | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
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Reference | H. Koike et al., J. Biochem., 126, 235 (1999) |
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