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| 名称 | PAR-3 (1-6),Protease Activated Receptor-3 (1-6), human |
| 编码 | [320347-28-2] |
| 别名 | PAR-3 (1-6),Protease Activated Receptor-3 (1-6), human |
| 纯度 | 80%，90%，95%，98%，99% |
| 重量 | 1mg,5mg,10mg,50mg,100mg,1g |
| 序列（单字母缩写） | TFRGAP |
| 序列（三字母缩写） | H-Thr-Phe-Arg-Gly-Ala-Pro-OH (trifluoroacetate salt) |
| 基本描述 | This peptide is a human PAR-3-derived tethered ligand, which does not activate PAR-3 but rather activates PAR-1 and PAR-2, either in Jurkat or in other PAR-expressing cells. PAR3 Tethered Ligand (Human) / Activates PAR1 and PAR2 This peptide is the 1-6 fragment of the protease-activated receptor 3 (PAR-3), which induces ERK activation in human carcinoma cells endogeneously expressing PAR1 and PAR3. This effect is completely abolished by single alanine substitution at positions 3, 4 and 6 in the peptide. PAR-3 allosterically regulates PAR1 signaling by receptor dimerization governing increased endothelial permeability. Targeting of PAR3 may mitigate the effects of PAR1 in activating endothelial responses such as vascular inflammation. However this peptide does not affect VEGF release or expression. |
| 溶解度 | |
| 分子量 | 647.73 |
| 化学式 | C29H45N9O8 |
| 存储条件 | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| 注释 | |
| Documents | ![PAR-3 (1-6),Protease Activated Receptor-3 (1-6), human 编码 [320347-28-2]](http://www.saliva.com.cn/wp-content/uploads/2022/10/20221005_633d2f04dc134.png) |
| Figures | ![PAR-3 (1-6),Protease Activated Receptor-3 (1-6), human 编码 [320347-28-2]](http://www.saliva.com.cn/wp-content/uploads/2022/10/20221005_633d2f053d6f8.jpg) |
| Reference | H.Ishihara et al., Nature, 386, 502 (1997) K.K. Hansen et al., Immunology, 112, 183 (2004) |
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