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名称 | (Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675) |
编码 | [150234-52-9] |
别名 | (Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675) |
纯度 | 80%,90%,95%,98%,99% |
重量 | 1mg,5mg,10mg,50mg,100mg,1g |
序列(单字母缩写) | SEVNLDAEF |
序列(三字母缩写) | H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-OH (trifluoroacetate salt) |
基本描述 | This peptide comprises a Cu2+-binding site. Binding of Cu2+ to the peptide induced oxidation of the cysteine and intermolecular dimerization of the peptide. The reduction of Cu2+ to Cu+ by Amyloid beta/A4 Protein Precursor may enhance the production of hydroxyl radicals which in turn may contribute to neurodegeneration in Alzheimer’s disease. |
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分子量 | 1023.1 |
化学式 | C44H66N10O18 |
存储条件 | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
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Reference | M. Citron et al., Nature, 360, 672 (1992) M. Mullan et al., Nature Gen., 1, 345 (1992) S.R. Sahasrabudhe et al., J. Biol. Chem., 268, 16699 (1993) |
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