Moradec Fab-αHFc-NC-MMAF说明书
Moradec LLC由Helen（Hongyuan）Mao博士于2012年创立，主要目标是为快速和经济的抗体 – 药物结合物发现提供新颖的研究工具。毛博士拥有超过14年的工业研发经验，包括主要制药公司，中小型生物技术公司。她近担任Fabrus的科学官，这是开发Fabrus Arrayed抗体筛选技术的关键。除了广泛的抗体优化专业知识外，她还积累了基于表皮生长因子受体的抗体治疗方法的丰富知识。在Fabrus之前，Mao博士领导了Biosite（现为Alere）抗体开发的蛋白质纯化组，先进的诊断公司，拥有用于开发诊断抗体的噬菌体展示平台技术。在Ansata Therapeutics，毛博士发明了基于分选酶的新型酶促蛋白质结合方法，该方法已经获得了研究应用，用于细胞表面标记，蛋白质阵列，核磁共振和蛋白质 – 药物结合等。毛医生进行了她的博士后诺华研究基金会（GNF）雅培实验室和基因组研究所的研究。她在麻省理工学院获得生物化学博士学位，在北京大学获得化学学士学位。毛在诺华研究基金会（GNF）的雅培实验室和基因组研究所进行了博士后研究。她在麻省理工学院获得生物化学博士学位，在北京大学获得化学学士学位。毛在诺华研究基金会（GNF）的雅培实验室和基因组研究所进行了博士后研究。她在麻省理工学院获得生物化学博士学位，在北京大学获得化学学士学位。
Moradec Fab-αHFc-NC-MMAF说明书
Fab-αHFc-NC-MMAF
FAB-αHFc-NC-MMAF
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具有不可切割接头的Fab抗人IgG Fc-MMAF抗体 |
目录编号：AH-201-AF |
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Fab-αHFc-NC-MMAF是与具有不可切割接头的单甲基auristatin F（MMAF）缀合的抗人IgG Fc特异性抗体的Fab片段。抗体部分是对人IgG的Fc区特异的多克隆抗体Fab片段。单甲基auristatin F（MMAF）是一种细胞毒性小分子，通过阻断微管蛋白的聚合来抑制细胞分裂。连接MMAF与抗体的不可切割接头在细胞外液中是稳定的，但是在进入细胞时可以通过未的机制切割。Fab 2°ADC的单价性质在某些应用中可能比全长IgG 2°ADC具有一些优势。 |
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二抗 – 药物偶联物目录
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Moradec的新型二抗 – 药物偶联物（2°ADC）是预先筛选抗体导联作为ADC候选物的重要研究工具。“他们工作非常出色，而且没有主要的ab，它们的毒性极低！ |
具有可切割接头的IgGs抗人IgG Fc-PBD抗体
具有可切割接头的IgGs抗小鼠IgG Fc-PBD抗体
具有可切割接头的IgG抗兔IgG（H + L）-PBD抗体
Anti-Human IgG (Fc Specific)
IgGs Anti-Human IgG (Fc Specific) ADCs
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Product Name |
Description |
Catalog No |
QTY |
Price |
|
αHFc-NC-MMAF |
IgGs Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker |
AH-101AF-50 |
50µg |
$330 |
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AH-101AF-20 |
20µg |
$165 |
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αHFc-CL-MMAF |
IgGs Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker |
AH-102AF-50 |
50µg |
$330 |
|
AH-102AF-20 |
20µg |
$165 |
||
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αHFc-CL-MMAE |
IgGs Anti-Human IgG Fc-MMAE Antibody with Cleavable Linker |
AH-102AE-50 |
50µg |
$330 |
|
AH-102AE-20 |
20µg |
$165 |
||
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αHFc-CL-DMSA |
IgGs Anti-Human IgG Fc-Duocarmycin SA Antibody with Cleavable Linker |
AH-102DS-50 |
50µg |
$330 |
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AH-102DS-20 |
20µg |
$165 |
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αHFc-CL-DMDM |
IgGs Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker |
AH-102DD-50 |
50µg |
$330 |
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AH-102DD-20 |
20µg |
$165 |
||
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αHFc-CL-PNU |
IgGs Anti-Human IgG Fc-PNU159682 Antibody with Cleavable Linker |
AH-102PN-50 |
50µg |
$330 |
|
AH-102PN-20 |
20µg |
$165 |
||
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αHFc-NC-DM1 |
IgGs Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker |
AH-103D1-50 |
50µg |
$330 |
|
AH-103D1-20 |
20µg |
$165 |
||
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αHFc-CL-PBD |
IgGs Anti-Human IgG Fc-PBD Antibody with Cleavable Linker |
AH-106PB-50 |
50µg |
$330 |
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AH-106PB-20 |
20µg |
$165 |
Fab Fragments of Anti-Human IgG (Fc Specific) ADCs
|
Product Name |
Description |
Catalog No |
QTY |
Price |
|
Fab-αHFc-NC-MMAF |
Fab Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker |
AH-201AF-50 |
50µg |
$440 |
|
AH-201AF-20 |
20µg |
$220 |
||
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Fab-αHFc-CL-MMAF |
Fab Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker |
AH-202AF-50 |
50µg |
$440 |
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AH-202AF-20 |
20µg |
$220 |
||
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Fab-αHFc-CL-MMAE |
Fab Anti-Human IgG Fc-MMAE Antibody with Cleavable Linker |
AH-202AE-50 |
50µg |
$440 |
|
AH-202AE-20 |
20µg |
$220 |
||
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Fab-αHFc-CL-DMSA |
Fab Anti-Human IgG Fc-Duocarmycin SA Antibody with Cleavable Linker |
AH-202DS-50 |
50µg |
$440 |
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AH-202DS-20 |
20µg |
$220 |
||
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Fab-αHFc-CL-DMDM |
Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker |
AH-202DD-50 |
50µg |
$440 |
|
AH-202DD-20 |
20µg |
$220 |
||
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Fab-αHFc-CL-PNU |
Fab Anti-Human IgG Fc-PNU159682 Antibody with Cleavable Linker |
AH-202PN-50 |
50µg |
$440 |
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AH-202PN-20 |
20µg |
$220 |
||
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Fab-αHFc-NC-DM1 |
Fab Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker |
AH-203D1-50 |
50µg |
$440 |
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AH-203D1-20 |
20µg |
$220 |
||
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Fab-αHFc-NC-AAMT |
Fab Anti-Human IgG Fc-Amanitin Antibody with Non-Cleavable Linker |
AH-20M-50 |
50µg |
$440 |
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AH-20M-20 |
20µg |
$220 |
Anti-Human IgG (Fab Specific)
IgGs Anti-Human IgG (Fab Specific) ADCs
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Product Name |
Description |
Catalog No |
QTY |
Price |
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αHFab-NC-MMAF |
IgGs Anti-Human IgG Fab-MMAF Antibody with Nonceavable Linker |
AH-121AF-50 |
50µg |
$360 |
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AH-121AF-20 |
20µg |
$180 |
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αHFab-CL-MMAF |
IgGs Anti-Human IgG Fab-MMAF Antibody with Cleavable Linker |
AH-122AF-50 |
50µg |
$360 |
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AH-122AF-20 |
20µg |
$180 |
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αHFab-CL-MMAE |
IgGs Anti-Human IgG Fab-MMAE Antibody with Cleavable Linker |
AH-122AE-50 |
50µg |
$360 |
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AH-122AE-20 |
20µg |
$180 |
||
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αHFab-NC-DM1 |
IgGs Anti-Human IgG Fab-DM1 Antibody with Non-Cleavable Linker |
AH-123D1-50 |
50µg |
$360 |
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AH-123D1-20 |
20µg |
$180 |
Anti-Mouse IgG (Fc Specific)
IgGs Anti-Mouse IgG (Fc specific) ADCs
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Product Name |
Description |
Catalog No |
QTY |
Price |
|
αMFc-NC-MMAF |
IgGs Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker |
AM-101AF-50 |
50µg |
$374 |
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AM-101AF-20 |
20µg |
$187 |
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αMFc-CL-MMAF |
IgGs Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker |
AM-102AF-50 |
50µg |
$374 |
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AM-102AF-20 |
20µg |
$187 |
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αMFc-CL-MMAE |
IgGs Anti-Mouse IgG Fc-MMAE Antibody with Cleavable Linker |
AM-102AE-50 |
50µg |
$374 |
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AM-102AE-20 |
20µg |
$187 |
||
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αMFc-CL-DMSA |
IgGs Anti-Mouse IgG Fc-Duocarmycin SA Antibody with Cleavable Linker |
AM-102DS-50 |
50µg |
$374 |
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AM-102DS-20 |
20µg |
$187 |
||
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αMFc-CL-DMDM |
IgGs Anti-Mouse IgG Fc-Duocarmycin DM Antibody with Cleavable Linker |
AM-102DD-50 |
50µg |
$374 |
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AM-102DD-20 |
20µg |
$187 |
||
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αMFc-CL-PNU |
IgGs Anti-Mouse IgG Fc-PNU159682 Antibody with Cleavable Linker |
AM-102PN-50 |
50µg |
$374 |
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AM-102PN-20 |
20µg |
$187 |
||
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αMFc-NC-DM1 |
IgGs Anti-Mouse IgG Fc-DM1 Antibody with Non-Cleavable Linker |
AM-103D1-50 |
50µg |
$374 |
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AM-103D1-20 |
20µg |
$187 |
||
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αMFc-CL-PBD |
IgGs Anti-Mouse IgG Fc-PBD Antibody with Cleavable Linker |
AM-106PB-50 |
50µg |
$374 |
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AM-106PB-20 |
20µg |
$187 |
Fab Fragments of Anti-Mouse IgG (Fc Specific) ADCs
|
Product Name |
Description |
Catalog No |
QTY |
Price |
|
Fab-αMFc-NC-MMAF |
Fab Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker |
AM-201AF-50 |
50µg |
$495 |
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AM-201AF-20 |
20µg |
$248 |
||
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Fab-αMFc-CL-MMAF |
Fab Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker |
AM-202AF-50 |
50µg |
$495 |
|
AM-202AF-20 |
20µg |
$248 |
||
|
Fab-αMFc-CL-MMAE |
Fab Anti-Mouse IgG Fc-MMAE Antibody with Cleavable Linker |
AM-202AE-50 |
50µg |
$495 |
|
AM-202AE-20 |
20µg |
$248 |
||
|
Fab-αMFc-CL-DMDM |
Fab Anti-Mouse IgG Fc-duocarmycin DM Antibody with Cleavable Linker |
AM-202DD-50 |
50µg |
$495 |
|
AM-202DD-20 |
20µg |
$248 |
||
|
Fab-αMFc-NC-DM1 |
Fab Anti-Mouse IgG Fc-DM1 Antibody with Noncleavable Linker |
AM-203D1-50 |
50µg |
$495 |
|
AM-203D1-20 |
20µg |
$248 |
Anti-Rabbit IgG (Fc Specific)
IgGs Anti-Rabbit IgG (Fc Specific) ADCs
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Product Name |
Description |
Catalog No |
QTY |
Price |
|
αOFc-NC-MMAF |
IgGs Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker |
AO-101AF-50 |
50µg |
$396 |
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AO-101AF-20 |
20µg |
$198 |
Fab Fragments of Anti-Rabbit IgG (Fc Specific) ADCs
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Product Name |
Description |
Catalog No |
QTY |
Price |
|
Fab-αOFc-NC-MMAF |
Fab Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker |
AO-201AF-50 |
50µg |
$528 |
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AO-201AF-20 |
20µg |
$264 |
Anti-Rabbit IgG(H+L)
IgGs Anti-Rabbit IgG (H+L) ADCs
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Product Name |
Description |
Catalog No |
QTY |
Price |
|
αOIgG-NC-MMAF |
IgGs Anti-Rabbit IgG(H+L)-MMAF Antibody with Non-Cleavable Linker |
AO-111AF-50 |
50µg |
$396 |
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AO-111AF-20 |
20µg |
$198 |
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αOIgG-CL-MMAF |
IgGs Anti-Rabbit IgG(H+L)-MMAF Antibody with Cleavable Linker |
AO-112AF-50 |
50µg |
$396 |
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AO-112AF-20 |
20µg |
$198 |
||
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αOIgG-CL-MMAE |
IgGs Anti-Rabbit IgG(H+L)-MMAE Antibody with Cleavable Linker |
AO-112AE-50 |
50µg |
$396 |
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AO-112AE-20 |
20µg |
$198 |
||
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αOIgG-CL-PBD |
IgGs Anti-Rabbit IgG(H+L)-PBD Antibody with Cleavable Linker |
AO-116PB-50 |
50µg |
$396 |
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AO-116PB-20 |
20µg |
$198 |
Fab Fragments of Anti-Rabbit IgG (H+L) ADCs
|
Product Name |
Description |
Catalog No |
QTY |
Price |
|
Fab-αOIgG-NC-MMAF |
Fab Anti-Rabbit IgG(H+L)-MMAF Antibody with Non-Cleavable Linker |
AO-211AF-50 |
50µg |
$528 |
|
AO-211AF-20 |
20µg |
$264 |
||
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Fab-αOIgG-CL-MMAF |
Fab Anti-Rabbit IgG(H+L)-MMAF Antibody with Cleavable Linker |
AO-212AF-50 |
50µg |
$528 |
|
AO-212AF-20 |
20µg |
$264 |
Anti-Rat IgG(Fc Specific)
IgGs Anti-Rat IgG (Fc Specific) ADCs
|
Product Name |
Description |
Catalog No |
QTY |
Price |
|
αRFc-NC-MMAF |
IgGs Anti-Rat IgG Fc-MMAF Antibody with Non-Cleavable Linker |
AR-101AF-50 |
50µg |
$396 |
|
AR-101AF-20 |
20µg |
$198 |
||
|
αRFc-CL-MMAF |
IgGs Anti-Rat IgG Fc-MMAF Antibody with Cleavable Linker |
AR-102AF-50 |
50µg |
$396 |
|
AR-102AF-20 |
20µg |
$198 |
Fab Fragments of Anti-Rat IgG (Fc Specific) ADCs
|
Product Name |
Description |
Catalog No |
QTY |
Price |
|
Fab-αRFc-NC-MMAF |
Fab Anti-Rat IgG Fc-MMAF Antibody with Non-Cleavable Linker |
AR-201AF-50 |
50µg |
$528 |
|
AR-201AF-20 |
20µg |
$264 |
||
|
Fab-αRFc-CL-MMAF |
Fab Anti-Rat IgG Fc-MMAF Antibody with Cleavable Linker |
AR-202AF-50 |
50µg |
$528 |
|
AR-202AF-20 |
20µg |
$264 |
||
|
Fab-αRFc-CL-MMAE |
Fab Anti-Rat IgG Fc-MMAE Antibody with Cleavable Linker |
AR-202AE-50 |
50µg |
$528 |
|
AR-202AE-20 |
20µg |
$264 |
||
|
Fab-αRFc-CL-DMDM |
Fab Anti-Rat IgG Fc-Duocarmycin DM Antibody with Cleavable Linker |
AR-202DD-50 |
50µg |
$528 |
|
AR-202DD-20 |
20µg |
$264 |
Anti-Rat IgG(H+L)
IgGs Anti-Rat IgG (H+L) ADCs
|
Product Name |
Description |
Catalog No |
QTY |
Price |
|
αRIgG-NC-MMAF |
IgGs Anti-Rat IgG(H+L)-MMAF Antibody with Non-Cleavable Linker |
AR-111AF-50 |
50µg |
$396 |
|
AR-111AF-20 |
20µg |
$198 |
Fab Fragments of Anti-Rat IgG (H+L) ADCs
|
Product Name |
Description |
Catalog No |
QTY |
Price |
|
Fab-αRIgG-NC-MMAF |
Fab Anti-Rat IgG(H+L)-MMAF Antibody with Non-Cleavable Linker |
AR-211AF-50 |
50µg |
$528 |
|
AR-211AF-20 |
20µg |
$264 |
||
|
Fab-αRIgG-CL-MMAF |
Fab Anti-Rat IgG(H+L)-MMAF Antibody with Cleavable Linker |
AR-212AF-50 |
50µg |
$528 |
|
AR-212AF-20 |
20µg |
$264 |
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